Long-lasting desynchronization by decoupling stimulation

Long-lasting neuronal desynchronization caused by coordinated reset neuromodulation

A number of brain diseases, e.g. movement disorders such as Parkinsons disease, are characterized by abnormal neuronal synchronization. Within the last years permanent high-frequency (HF) deep brain stimulation became the standard therapy for medically refractory movement disorders. To overcome limitations of standard HF deep brain stimulation, we use a model based approach. To this end, we mak...

P45: Long-Lasting Effects of Repetitive Transcranial Magnetic Stimulation on Anxiety-Like Behaviors in Schizophrenic Developmental Model

Transcranial magnetic stimulation (TMS) has been applied to a growing number of psychiatric disorders as a neurophysiological probe, a primary brain-mapping tool and a candidate treatment. Although most investigations have focused on the treatment of major depression, increasing attention has been paid to anxiety disorders. The aim of this study is to long time (for 30 days) effect of repetitiv...

Effective desynchronization with bipolar double-pulse stimulation.

This paper is devoted to the desynchronizing effects of bipolar stimuli on a synchronized cluster of globally coupled phase oscillators. The bipolar pulses considered here are symmetrical and consist of a positive and a negative monopolar pulse. A bipolar single pulse with the right intensity and duration desynchronizes a synchronized cluster provided the stimulus is administered at a vulnerabl...

Random stimulation of spider mechanosensory neurons reveals long-lasting excitation by GABA and muscimol.

gamma-Aminobutyric acid type A (GABA(A)) receptor activation inhibits many primary afferent neurons by depolarization and increased membrane conductance. Deterministic (step and sinusoidal) functions are commonly used as stimuli to test such inhibition. We found that when the VS-3 mechanosensory neurons innervating the spider lyriform slit-sense organ were stimulated by randomly varying white-n...

Muscimol Reveals Long-Lasting Excitation by GABA and Random Stimulation of Spider Mechanosensory Neurons